![]() 9 Depression and anxiety are among the most common, affecting 45%–50% and 20%–40% of individuals with FASD, respectively. 3–5 Beyond the primary cognitive and behavioural deficits, over 90% of individuals with FASD experience co-occurring mental health problems, 6–8 compared with 20% in the general population. 1 The prevalence of FASD in North America is estimated to be 4%, 2 3 with lifetime costs over $C 1 million per individual. ![]() It is characterised by life-long cognitive, behavioural and neurological deficits. This project will forge new understanding of FASD and mental health from a neurobiological perspective, highlighting key time periods (ie, sensitive windows) and brain regions (ie, that may be susceptible to neurostimulation), while identifying factors that predict individual trajectories of anxiety and depression symptoms.įetal alcohol spectrum disorder (FASD) is a neurodevelopmental disorder caused by prenatal alcohol exposure (PAE). All of this will be done while considering sex and adverse postnatal experiences, which can significantly impact mental health and brain outcomes. We will use longitudinal neuroimaging (anatomical T1-weighted, diffusion and passive viewing function MRI) and mental health assessments (Behaviour Assessment Scale for Children, Multi-dimensional Anxiety Scale for Children, Children’s Depression Inventory (CDI-2), Kiddie Scale of Affective Disorders) to: (1) characterise brain development trajectories in youth with FASD, (2) determine whether brain alterations mediate increased anxiety and depression in youth with FASD and (3) identify baseline brain features that predict changes of anxiety and depression symptoms over the next 2 years. Methods and analysis The Prenatal Exposure And Child brain and mental Health (PEACH) study includes children aged 7–18 years.
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